Dental Anatomy – Teeth Whitening Ireland http://teethwhiteningireland.com/ Fri, 17 Sep 2021 21:43:24 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://teethwhiteningireland.com/wp-content/uploads/2021/06/icon-1.png Dental Anatomy – Teeth Whitening Ireland http://teethwhiteningireland.com/ 32 32 Stratasys Direct expands 3D printing services for healthcare industry – 3DPrint.com https://teethwhiteningireland.com/stratasys-direct-expands-3d-printing-services-for-healthcare-industry-3dprint-com/ https://teethwhiteningireland.com/stratasys-direct-expands-3d-printing-services-for-healthcare-industry-3dprint-com/#respond Fri, 17 Sep 2021 13:01:08 +0000 https://teethwhiteningireland.com/stratasys-direct-expands-3d-printing-services-for-healthcare-industry-3dprint-com/ Stratasys Direct Manufacturing has announced the opening of a dedicated healthcare printing center at its newly opened PolyJet design and printing center in Eden Prairie, Minnesota. The new addition expands the company’s on-demand offerings to the healthcare industry to include anatomical modeling, full-service anatomical model design, and consulting services, including design transfer and process validation. […]]]>

Stratasys Direct Manufacturing has announced the opening of a dedicated healthcare printing center at its newly opened PolyJet design and printing center in Eden Prairie, Minnesota. The new addition expands the company’s on-demand offerings to the healthcare industry to include anatomical modeling, full-service anatomical model design, and consulting services, including design transfer and process validation. This is one of several announcements made by the industrial 3D printing manufacturer at the RAPID + TCT 2021 conference, which took place September 13-15 in Chicago.

Eden Prairie Medical Printing Center has Stratasys J750 digital anatomy printers, which enable company engineers to produce realistic 3D printed medical and dental anatomical models for medical device manufacturers and service providers health care. Launched in November 2019, the J750 Digital Anatomy printer creates models of human anatomy that mimic the real feel, responsiveness and biomechanical properties of bones, vessels and organs at an unprecedented level of realism. These features allow customers to recreate pathologies and minimize the use of cadavers or animals for clinical trials and surgical training.

Stratasys J750 Digital Anatomy can help standardize surgical skills and care delivery by practicing the most accurate representation of the pathology of interest. Image courtesy of Stratasys

In the first 13 weeks of operation, as an invite-only beta service for major medical device manufacturers, Stratasys Direct has already 3D printed over 1,000 models, with each machine running over 120 hours per week . In addition, in collaboration with its beta customers, Stratasys Direct has created anatomical models for product demonstrations, surgical education events for physicians and internal product development activities, in the hope of opening up new possibilities. for complex and anatomically accurate models at a lower cost than traditional manufacturing methods.

Hospitals, healthcare providers, and medical schools are already using these realistic 3D models for device testing, medical training, or surgical preparation and consultation, including practice mannequins, teaching aids, and surgery. preoperative planning. In fact, Stratasys Americas President Rich Garrity has said that adding digital anatomy printers to Stratasys Direct would provide businesses with previously limited access to these printing capabilities the ability to use its services from manufacturing to 3D print the exact anatomical models they need.

3D printed spinal pedicel screw insertion with Stratasys J750 Digital.

3D printed spinal pedicel screw insertion with the Stratasys J750 Digital Anatomy platform. Image courtesy of Stratasys.

For example, users can choose the printer’s preprogrammed cardiac or vascular applications, automatically selecting the necessary materials based on parameters chosen for a specific reproduction, enabling what Stratasys describes as “precise experience of procedures”, such as cutting and suturing, placement and correction of the device. The machine can produce cardiac models that mimic very fine anatomy, such as cord tendons, valve leaflets, and rings, or reproduce the feel, function, and dimensions of vascular models that recreate both healthy and diseased vessels.

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Known for researching next-generation technologies to help treat vascular disease, the Jacobs Institute (JI) in Buffalo, New York, has used 3D printing for years to create realistic medical models that can validate new devices and help medical teams to prepare for difficult procedures. Now the JI leverages the Stratasys J750 Digital Anatomy platform and materials to achieve a new level of realism. In fact, the US-Israel company said that three new materials specifically designed for medical modeling applications set the digital anatomy printer apart from other solutions.

Jacobs Institute expert removing a vascular model from the Stratasys J750 Digital Anatomy printer.

Jacobs Institute expert removing a vascular model from the Stratasys J750 Digital Anatomy printer. Image courtesy of Jacobs Institute / Stratasys.

The medical model 3D printer niche is dominated by a group of renowned companies in the industry, including Stratasys and its J750; Ultimaker’s S5 printer, certified by Materialize; popular Mimaki printers used for medical modeling; BCN3D’s professional desktop FFF printers that help physicians build biomodels; and a handful of companies that have long been developing medical models like EnvisionTEC (which was acquired by Desktop Metal in early 2021), 3D Systems, and HP’s 3D printers.

3D printed vascular models designed by the Jacobs Institute

Vascular models designed by the Jacobs Institute and 3D printed using Stratasys J750 Digital Anatomy. Image courtesy of Stratasys.

Using powerful digital anatomy software and materials like GelMatrix, a carrier substance designed to be easily removed from vascular models with small interior diameters and thin walls, or the incredibly soft and translucent TissueMatrix material, ideal for replicating the look and feel of the heart tissue that has helped health care providers improve preparation for surgery. The company even created an intricate material that mimics porous bone structures, fibrous tissue, and ligaments, providing realistic feedback when cutting and drilling. Called BoneMatrix, it is ideal for orthopedic applications, a rapidly growing market within the healthcare industry.

A year after the launch of the J750 Digital Anatomy printer, Stratasys said it has been sold and successfully installed in healthcare facilities and medical service providers in major markets around the world, including Seattle Children’s Hospital, the US Veterans Affairs (VA) Health Care System, Nicklaus Children’s Hospital in Miami, Medilife and BIO3DModel in Italy, and Tknika and AIJU in Spain.


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Zimmer Biomet spin-off to be called ZimVie https://teethwhiteningireland.com/zimmer-biomet-spin-off-to-be-called-zimvie/ https://teethwhiteningireland.com/zimmer-biomet-spin-off-to-be-called-zimvie/#respond Thu, 16 Sep 2021 21:26:35 +0000 https://teethwhiteningireland.com/zimmer-biomet-spin-off-to-be-called-zimvie/ Zimmer Biomet (NYSE: ZBH) announced today that the planned split of its spinal and dental business will be called ZimVie. Spokeswoman Laura Driscoll explained that “Zim” derives from Zimmer Biomet, the roots of the new company – and “Vie” is the French word for “life”, symbolizing the future. (Abbott used a similar build with its […]]]>

Zimmer Biomet (NYSE: ZBH) announced today that the planned split of its spinal and dental business will be called ZimVie.

Spokeswoman Laura Driscoll explained that “Zim” derives from Zimmer Biomet, the roots of the new company – and “Vie” is the French word for “life”, symbolizing the future. (Abbott used a similar build with its pharmaceutical spin-off AbbVie.) ZimVie’s corporate headquarters will be in Westminster, Colorado.

The news came at the same time that Zimmer Biomet announced other executive appointments of the spin-off, including Richard J. Heppenstall as executive vice president and chief financial officer. Heppenstall most recently served as CFO of Breg and previously held executive positions at Orthofix International, Solera Holdings, Flowserve and Coopervision, among others. He will report directly to Vafa Jamali, the former Medtronic executive announced as CEO of the spin-off earlier this year.

“Rich is joining ZimVie at a pivotal time for the company as we continue to shape our operating model and business plans in preparation for the planned spinoff,” Jamali said in a press release. “His extensive experience in all areas of finance within the medtech space will be of critical importance as we move towards forming a new independent company for our Spine and Dental businesses.”

The creation of ZimVie remains on track, with a closure expected in mid-2022.

Other appointments from the ZimVie leadership team include:

  • Vincent binetti, GM, Bone healing;
  • Laura Driscoll, Vice-President, Communications;
  • David Harmon, Senior Vice-President, Director of Human Resources;
  • Indraneel Kanaglekar, Senior Vice President, President, Global Dental;
  • Heather kidwell, SVP, Chief Legal and Compliance Officer;
  • Mike minette, SVP, Strategy and business development;
  • Ann Vu, SVP, Regulatory Affairs and Quality Assurance;
  • Rebecca whitney, SVP, President, Global Spine.

This story was originally published on September 14. Updated September 16 with more details.


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CDA-sponsored bill allows dentists to obtain registration required to perform rapid in-office COVID-19 tests https://teethwhiteningireland.com/cda-sponsored-bill-allows-dentists-to-obtain-registration-required-to-perform-rapid-in-office-covid-19-tests/ https://teethwhiteningireland.com/cda-sponsored-bill-allows-dentists-to-obtain-registration-required-to-perform-rapid-in-office-covid-19-tests/#respond Thu, 16 Sep 2021 19:27:37 +0000 https://teethwhiteningireland.com/cda-sponsored-bill-allows-dentists-to-obtain-registration-required-to-perform-rapid-in-office-covid-19-tests/ Governor Gavin Newsom is expected to sign CDA-sponsored legislation that gives California dentists permanent authority to provide influenza and COVID-19 vaccines and obtain state registration required to perform COVID-testing. 19 fast in the dental office. AB 526, written by Assembly Member Jim Wood, DDS (D-Santa Rosa), overcomes two significant hurdles for California dentists managing patient […]]]>

Governor Gavin Newsom is expected to sign CDA-sponsored legislation that gives California dentists permanent authority to provide influenza and COVID-19 vaccines and obtain state registration required to perform COVID-testing. 19 fast in the dental office.

AB 526, written by Assembly Member Jim Wood, DDS (D-Santa Rosa), overcomes two significant hurdles for California dentists managing patient care, especially during the ongoing pandemic.

First, it allows them to independently prescribe and administer influenza and COVID-19 vaccines in accordance with federal immunization schedules published by the Centers for Disease Control and Prevention. Second, it allows dentists to obtain the California Laboratory Field Services license to perform dispensed tests, such as rapid point-of-care COVID-19 tests, which would not only protect dentists and their staff, but could help dentists to comply with COVID-19. testing requirement under the state’s public health ordinance that went into effect Aug. 23.

The Legislature passed the bill on September 8 as emergency law, meaning it will come into force as soon as the governor signs it. His deadline for signing is October 10 for bills from the current legislative session.

Bill codifies DCA waiver allowing dentists to provide COVID-19 vaccines

Many California dentists who have completed the required training from the Centers for Disease Control and Prevention have been administering COVID-19 vaccines on a temporary basis since the Department of Consumer Affairs issued a waiver in January to increase the number of eligible vaccinators during the period. public health emergency.

As the CDA stated in a letter requesting the support of the Legislature: “Dentists are well equipped to administer vaccines because they regularly perform injections in particularly sensitive areas of the mouth… and have extensive training in microbiology. , autoimmune response, general anatomy, pharmacology and IV. “

By codifying the DCA waiver and federal PREP law, AB 526 authorizes dentists to prescribe and administer FDA-approved or authorized influenza and COVID-19 vaccines to persons 3 years of age and older. The bill also specifies that CDC vaccine training will count toward a dentist’s continuing education requirements.

Bill clears way for dentists to perform rapid COVID-19 tests in dental offices

The AB 526 also allows dentists to obtain the appropriate state registration in addition to their federal CLIA certificate, so that performing simple and reliable tests, such as rapid point-of-care COVID-19 tests, falls within the scope of dental practice.

“Dentists must be able to promptly screen all patients prior to dental treatment in order to protect the dental team from exposure to COVID-19 and to help refer asymptomatic and COVID-positive patients to appropriate care” , wrote the ADC in a letter to the state legislature.

And now, with California’s July 26 public health order requiring all health care workers in the state, including dentists and dental staff, to be fully vaccinated against or tested regularly for COVID-19, the need for dentists to have the ability to carry out simple actions, reliable tests in the dental office has become more urgent.

Currently, dentists can obtain their CLIA exemption certificate through the Centers for Medicare and Medicaid Services, which is required to perform waived testing. Tests are classified as exempt if the risk of misinterpreted results is low and the administration of the tests can be followed according to the instructions of the test manufacturer.

However, dentists are not eligible to obtain the registration required by the California Department of Public Health Laboratory Field Services because they are not on the list of people who may supervise the tests being performed.

This will change when AB 526 goes into effect in the coming weeks. AB 526 aligns California’s Laboratory Registration Act with federal law and allows dentists to register in the state as a “lab manager” to perform tests without waivers.

“Dentists have a training equivalent to that of other providers who can register as a laboratory director and therefore should also be allowed to supervise simple and low-complexity tests,” said CDA President Judee Tippett -Whyte, DDS. “With the arrival of rapid point-of-care COVID-19 tests on the market, the adoption of this legislation is all the more critical for the immediate screening of patients and employees to ensure the safety of dental teams and patients. “

Once the legislation comes into force, dentists may also perform certain FDA-approved COVID-19 antigen tests for self-administration to comply with the weekly COVID-19 testing mandate for College employees. state public health. More information is available in CDA’s COVID-19 Lab Testing Toolkit.

CDA continues to seek clarification on who bears the costs of employee testing

As of August 23, dentists and dental staff in California who are not fully vaccinated against COVID-19 must undergo weekly COVID-19 tests under the state’s public health order. The CDA continues to seek clarification from state officials as to whether the dentist employer should bear the cost of the tests, including paying employees for weekly tests out of the office.

CDA encourages dentists to read CDA’s regularly updated FAQ on Mandate for Vaccination or Health Testing. Dental offices in San Francisco and Los Angeles counties will soon have to comply with local immunization orders.


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Stratasys Direct Manufacturing Medical Printing Services https://teethwhiteningireland.com/stratasys-direct-manufacturing-medical-printing-services/ https://teethwhiteningireland.com/stratasys-direct-manufacturing-medical-printing-services/#respond Thu, 16 Sep 2021 11:01:39 +0000 https://teethwhiteningireland.com/stratasys-direct-manufacturing-medical-printing-services/ AlphaCoin Appoints Alec Searle Chief Executive Officer AlphaCoin LLC announced that Alec Searle will become the new President and CEO of the Connecticut-based manufacturer of high-precision components for the aerospace, defense and medical industries. Searle has joined AlphaCoin September 1, 2021. Searle brings more than two decades of experience in the aerospace and defense industry […]]]>

AlphaCoin Appoints Alec Searle Chief Executive Officer

AlphaCoin LLC announced that Alec Searle will become the new President and CEO of the Connecticut-based manufacturer of high-precision components for the aerospace, defense and medical industries. Searle has joined AlphaCoin September 1, 2021.

Searle brings more than two decades of experience in the aerospace and defense industry to AlphaCoin. Before joining AlphaCoin, Searle was COO of Paradigm Precision, a leading privately owned manufacturing and machining company. AlphaCoin’s business units include GAR Electroforming from Danbury, Connecticut, Connecticut Coining from Bethel, Connecticut and Gasser from Commack, NY

As President and CEO of AlphaCoin, Searle will be responsible for the current and growing platform of the three business units, providing strategic advice, leadership and management to the existing platform and helping to develop the business through strategic acquisitions.

“Alec is the right leader for the AlphaCoin wallet,” says Gary Schuster, President of AlphaCoin. “Alec’s extensive experience in aerospace and defense manufacturing, combined with his leadership skills, will help strengthen and further develop the AlphaCoin portfolio. “

“I am delighted and honored to lead the AlphaCoin team,” said Searle. “I was drawn to AlphaCoin because of the unmatched range of manufacturing capabilities and the team’s strong desire to partner with clients for the long term. I look forward to working both internally and externally to strengthen and develop our capabilities and be the partner of choice for the products we offer.

Searle, a resident of Burlington, Connecticut, has been the COO of Paradigm Precision since 2018.

HB Carbide appoints new CEO

Carbide HB announced Jon Dreher as its new Managing Director, responsible for overseeing all of the company’s operations to meet expected revenue targets while maintaining quality standards and staff satisfaction.

With extensive operational experience in manufacturing as well as association management, Dreher served as Executive Chairman of the Grand Traverse Area Manufacturing Council for five years. He has worked with companies ranging from the 500 Inc. to start-ups to running his own global business for 14 years. Most recently, he was Vice President of Promethient Inc. (Traverse City), an air conditioning solutions provider.

Dreher holds a Bachelor of Science in Mechanical Engineering from Michigan State University and is certified in Six Sigma, Lean, and Quick Response Manufacturing. Community service work includes her involvement as a robotics coach in support of the VEX Robotics Students. He lives in Williamsburg with his wife and children.

Norman Noble Inc. celebrates 75 years of innovation in Cleveland

Norman Noble Inc., the world’s leading contract manufacturer of next-generation medical implants, celebrates its 75th year of operation in northeast Ohio.

The company was founded in 1946 in Cleveland. Today, 3 generations of the Noble family maintain the guiding principles for running the business – and the industry – with technologically advanced capabilities and exceptional service. The company now has 750 employees, 5 facilities and over 275,000 square feet of combined manufacturing space. Headquarters and large-scale production facilities are located in Highland Heights, Ohio, with additional facilities in Naples, Florida, and Windsor, Ontario, Canada.

Norman Noble Inc. keeps pace with current technology by continually investing in machining, finishing and engineering resources to enable the manufacture of next generation product designs. Recent manufacturing innovations include its proprietary Noble STEALTH athermal lasers for machining Class III nitinol implants, its 5-axis dimensional inspection system, its CT scanner inspection system, SynchroFlash operation combining l laser machining with Swiss turning and milling, fully validated manufacturing processes and rapid development prototyping services.

Medtech product designs that Noble Norman Manufacturers for OEM customers include transcatheter heart valve frame and pump components, vascular stents (neurovascular, cardiovascular, carotid, peripheral SFA, venous and BTK), neurovascular clot removal devices, closure implants vessel, spinal implants, orthopedic screws and plates, and leaf collimator multi-sets used for radiotherapy.

For implant and medical device companies in need of a manufacturing partner, Norman Noble’s US-based engineering team offers solutions to guide the most complex implant and medical device designs. of new generation, from prototype to commercialization. With in-house nitinol experts and unmatched ability as the world’s largest contract laser manufacturer, Norman Noble works quickly to manufacture and validate anything that can be designed.

DATRON Dynamics Celebrates 25th Anniversary and Donates $ 25,000 of Tooling to STEM Programs

Dynamique DATRON inc., North American supplier of high-speed precision CNC machines DATRON, celebrates its 25th anniversary by donating $ 25,000 of cutting tools to ten educational institutions that have DATRON machines in their STEM program.

Each of the selected institutions, including the University of Oregon, the University of New Hampshire, the University of Maryland, the University of Western Ontario, the University of Washington, the University of Southern New Hampshire, the Laval University and Mount Si High School of the Snoqualmie The Valley School District and two others will receive a $ 2,500 voucher to purchase cutting tools for their DATRON machines.

Created in 1996, Dynamic DATRON brings smart manufacturing solutions to a variety of industries. DATRON cutting machines and tools are German designed for precision, ease of use and speed. The exclusive DATRON line of end mills are designed to increase throughput and provide superior surface finishes.

Asked about this important anniversary, Bill King, President of DATRON Dynamics, Inc. said, “DATRON Dynamics believes that the best way to honor this milestone is to invest in training programs that develop our next generation of engineers, machinists and manufacturers. . I am grateful to DATRON AG for allowing us to represent this cutting edge technology, to our incredible team of dedicated employees for their tireless efforts and expertise, and finally to our customers, who have trusted us to be a part of their growth and of their vision. . I couldn’t be more proud of what our team has built and accomplished over the past 25 years.

ARCH Medical Solutions Corp. acquires Wilsey Tool Co., Isimac Mfg. Co. and Choice Precision

ARCH Medical Solutions Corp., a Global Precision Company ARCH announced the acquisition of three companies from VfD Technologies: Wilsey Tool Co. Inc. in Quakertown, Pennsylvania; Isimac Mfg. Co. Inc. in Blandon, Pennsylvania; and Choice Precision Inc. in Whitehall, Pennsylvania. Each company specializes in precision custom manufacturing for the medical device industry with additional expertise in machining robotic effectors for specialty robotics and factory automation applications. In addition, the companies serve many customers in other complementary industries. The new acquisitions join ARCH Medical Solutions collectively as ARCH Medical Solutions – Lehigh Valley, consolidating ARCH as a leading industry supplier known for its growth and scale in the medical products market.

“These companies are an exciting addition to the ARCH family,” said Paul Barck, division president of ARCH Medical Solutions. “During my site visits, I saw first-hand sophisticated manufacturing processes and a culture very focused on quality and productivity, which aligns well with our approach. The capabilities of Wilsey, Isimac and Choice are highly complementary to the existing capabilities and expertise of ARCH Medical Solutions. “

Elizabeth Rothwell, Commercial Director at VfD and current President of ARCH Medical Solutions – Lehigh Valley, sees this partnership as a platform for growth in the contract medical device and automation markets.

“Given the strength of the VfD Technologies and ARCH Medical Solutions teams, our customers and employees stand to gain from this partnership,” says Rothwell. “By joining forces, we will be able to offer expanded capabilities and capabilities to our customers, and our employees will have expanded growth and development opportunities. “

“The growth we are facing is enormous and ARCH offers extensive resources to secure the future of the business. After evaluating many options, we identified ARCH Medical Solutions as the right partner, ”says Patrick Thornton, CFO at VfD and vice president of finance for ARCH Medical Solutions – Lehigh Valley.

ARCH President and CEO Eli Crotzer believes the combined expertise of the three companies is a perfect match for ARCH.

“As we got to know the whole business, we noticed a lot of similarities between us,” he said. “I am convinced that these common values ​​will allow seamless integration. “


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Stratasys Expands Anatomical Modeling Services for Healthcare https://teethwhiteningireland.com/stratasys-expands-anatomical-modeling-services-for-healthcare/ https://teethwhiteningireland.com/stratasys-expands-anatomical-modeling-services-for-healthcare/#respond Tue, 14 Sep 2021 17:40:54 +0000 https://teethwhiteningireland.com/stratasys-expands-anatomical-modeling-services-for-healthcare/ A Stratasys 3D printed anatomical model of a spinal pedicel screw insertion (Photo courtesy of Stratasys) Stratasys Direct Manufacturing now offers anatomical modeling and consulting services for the healthcare industry. Affiliate Stratasys (NASDAQ: SSYS) opened its new healthcare printing center in Eden Prairie, Minnesota, and smoothly launched the new offerings with an invite-only beta testing […]]]>

A Stratasys 3D printed anatomical model of a spinal pedicel screw insertion (Photo courtesy of Stratasys)

Stratasys Direct Manufacturing now offers anatomical modeling and consulting services for the healthcare industry.

Affiliate Stratasys (NASDAQ: SSYS) opened its new healthcare printing center in Eden Prairie, Minnesota, and smoothly launched the new offerings with an invite-only beta testing for medical device manufacturers. Over the past 13 weeks, the Stratasys J750 Digital Anatomy printers have created over 1,000 models, with each printer operating over 120 hours per week.

Printers create realistic medical and dental anatomical models for medical device manufacturers and healthcare providers to use in device testing, medical education, or surgical preparation and consultation. Stratasys launched the printers in 2019 and updated them with biomechanically realistic bone capacities in 2020.

“The J750 digital anatomy printer can produce models that mimic the biomechanical properties of bone, vascular system and organ tissue, allowing customers to recreate pathologies not supported by cadavers or animals,” said Stratasys in a press release.

“We can now provide companies with previously limited access to these printing capabilities the ability to use Stratasys Direct’s manufacturing services to 3D print anatomical models that meet their exact specifications,” said Rich Garrity, president of Stratasys Americas, in the press release.

Stratasys said it now also offers full anatomical model design and consulting services, including design transfer and process validation.

Stratasys has two headquarters in Eden Prairie and Rehovot, Israel.


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The first rat model recapitulates all the disabling alterations suffered by patients with Morquio A disease https://teethwhiteningireland.com/the-first-rat-model-recapitulates-all-the-disabling-alterations-suffered-by-patients-with-morquio-a-disease/ https://teethwhiteningireland.com/the-first-rat-model-recapitulates-all-the-disabling-alterations-suffered-by-patients-with-morquio-a-disease/#respond Sun, 12 Sep 2021 17:15:00 +0000 https://teethwhiteningireland.com/the-first-rat-model-recapitulates-all-the-disabling-alterations-suffered-by-patients-with-morquio-a-disease/ A research team from the Universitat Autònoma de Barcelona (UAB) generated the first rat model recapitulating all the debilitating alterations experienced by patients with mucopolysaccharidosis type IVA, also known as Morquio A disease. team developed gene therapy that completely corrects severe whole-body alterations in the rat model after a single intravenous viral vector administration. The […]]]>

A research team from the Universitat Autònoma de Barcelona (UAB) generated the first rat model recapitulating all the debilitating alterations experienced by patients with mucopolysaccharidosis type IVA, also known as Morquio A disease. team developed gene therapy that completely corrects severe whole-body alterations in the rat model after a single intravenous viral vector administration. The research opens the door to a future therapy that could be administered at a young age in patients diagnosed with this rare disease, thereby preventing bone deformities, osteoarthritis complications and other life-threatening alterations.

Mucopolysaccharidosis type IVA, also known as Morquio A disease, is a rare disease caused by a deficiency of the GALNS enzyme, which causes alterations in bone growth (skeletal dysplasia), rapid deterioration of cartilage, and complications in the heart and trachea that lead to cardiorespiratory complications that can lead to premature death. The first symptoms are detected in very young children (around 2 years old), and in the most severe cases, death usually occurs around the age of 20. There is no cure for this disease and current therapy, based on enzyme replacement, cannot correct skeletal abnormalities.

UAB researchers generated the first rat model of Morquio A disease that fully mimics the severity of the disease, unlike existing mouse models, especially skeletal dysplasia, early cartilage deterioration and valve alterations. heart and trachea, in the same way as human patients. Using CRISPR / Cas9 genome editing technology, the authors generated a rat with a mutation in the genome that causes the most common and severe form of the disease in humans.

Subsequently, the researchers developed the first gene therapy approach that reversed the entire plethora of pathological alterations in Morquio A disease in the new rat model. This gene therapy is based on the intravenous administration of a viral vector encoding the GALNS enzyme. Gene therapy induced widespread biodistribution and ubiquitous expression of the therapeutic gene, particularly throughout the skeletal system. This allowed the long-term production of the enzyme in all affected tissues, thus preventing damage to the bones, as well as to the cartilage, trachea and heart.

Administration of gene therapy to four week old Morquio A rats completely reversed the clinical signs of the disease, such as alterations in bone growth, dental deformities and brittleness, pathology of joint cartilage, as well as respiratory and cardiovascular complications. “

Fatima Bosch, UAB researcher and study director

Currently, no gene therapy approach is applied to treat Morquio A patients. This new therapy developed at UAB results in sustained production of the enzyme throughout the body and in particular in the bones. Therefore, it could be used to treat children diagnosed with the disease at an early age, when bone formation is very active and the skeletal changes are not irreversible.

“The gene therapy developed by our team has the potential to correct the crippling Morquio A disease in humans. Nevertheless, studies examining the biodistribution and the long-term safety of the therapeutic vector in large animals are needed before moving the treatment to the clinical phase, ”Dr. Bosch concludes.

The study, published September 9 in Nature Communications, was coordinated by UAB researcher Fàtima Bosch, who is also director of the Center for Animal Biotechnology and Gene Therapy (CBATEG) at UAB. The work was carried out by researchers from CBATEG and from the Departments of Biochemistry and Molecular Biology, Animal Health and Anatomy, UAB School of Veterinary Medicine; the Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM); and the Molecular Imaging Unit of the Spanish National Cancer Research Center (CNIO).

Source:

Universitat Autònoma de Barcelona


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Sinoscopy in the standing horse https://teethwhiteningireland.com/sinoscopy-in-the-standing-horse/ https://teethwhiteningireland.com/sinoscopy-in-the-standing-horse/#respond Fri, 10 Sep 2021 14:51:12 +0000 https://teethwhiteningireland.com/sinoscopy-in-the-standing-horse/ Sinoscopy is a minimally invasive diagnostic procedure that can be performed on the standing horse. The technique can allow good visualization and treatment of paranasal sinus disease and eliminate the need for more invasive procedures such as large bone flaps. Knowledge of the anatomy of the paranasal sinuses is the most important aspect of the […]]]>

Sinoscopy is a minimally invasive diagnostic procedure that can be performed on the standing horse. The technique can allow good visualization and treatment of paranasal sinus disease and eliminate the need for more invasive procedures such as large bone flaps. Knowledge of the anatomy of the paranasal sinuses is the most important aspect of the procedure.

Paranasal sinus disorders include primary or secondary sinusitis, progressive ethmoid hematoma, sinus cysts and, more rarely, neoplasia. Due to the size and complex anatomy, these pathological processes can sometimes be present for weeks or months before clinical signs such as a runny nose or swelling of the face are evident.1 Treating chronic equine paranasal sinus disorders can be frustrating, but the long-term prognosis is usually excellent unless the diagnosis is neoplasia.2

Imaging of the paranasal sinuses is essential for diagnosis and surgical planning in affected horses. Radiography and computed tomography (CT) are the most commonly used. Sinoscopy is a simple and minimally invasive procedure compared to traditional paranasal sinus surgical approaches, potentially reducing the incidence of complications. It also provides a way to more accurately diagnose, and subsequently treat, certain underlying conditions. Sinoscopy has been reported as the most useful diagnostic tool compared to radiography and endoscopy in horses with sinus pathology. It allowed an exact diagnosis in 70% of patients, against endoscopy in 20% and radiography in 36%. Changes including thickening or inflammation of the sinus lining, lesions occupying space, exudate, associated dental abscesses, and fungal lesions can be diagnosed using this modality.1

The horse has 6 paired paranasal sinuses (frontal, rostral maxilla, caudal maxilla, sphenopalatine and the dorsal and ventral conch sinuses) which communicate with each other and with the nasal passage directly or indirectly. The frontal sinus and the maxillary caudal sinus communicate by the frontomaxillary orifice; the sphenopalatine and the caudal maxillary sinus communicate through the sphenopalatine orifice; and the rostral maxilla and ventral conch sinus communicate via the conchomaxillary opening. A thorough understanding of spatial structural relationships is crucial for successful surgery in the region.3

Sinoscopy can be performed under standing sedation using a sterile flexible arthroscope or fiberscope or a video endoscope via a conchofrontal or rostral maxillary trephine opening. The trepanation site is prepared for surgery and desensitized by subcutaneous injection of local anesthetics. Sinoscopy gates are made in the frontal or maxillary bone after skin incisions, using a 9.5 mm to 15 mm Galt trephine. Initial irrigation or aspiration may be necessary to improve visualization if the sinus compartments are filled with exudate. The skin incision is closed with staples or skin sutures after the sinoscopy is complete.

Sinus compartments that can be visualized directly through a conchofrontal trephine portal include the frontal, caudal maxilla, and dorsal conch sinuses. The ethmoid turbinates, the frontomaxillary opening and the nasomaxillary opening are also visible. Structures observed in the maxillary caudal sinus include the infraorbital canal, the apices of the 10th and 11th maxillary jaw teeth, the maxillary septum, and the entrance to the sphenopalatine sinus.4 The same structures can be seen through an opening of the maxillary rostral trephine, but the entrance to the sphenopalatine sinus may not be accessible.

The maxillary rostral sinus and the ventral conch sinus are frequent sites of infection caused by apical dental infection or inspected exudate, respectively. However, these sinuses are not directly accessible from the trephine holes in the conchofrontal or caudal maxillary sinuses (Figure 1). The maxillary rostral sinus can be examined independently by a maxillary bone trepanation placed rostrally. However, this is generally not recommended in young horses to avoid iatrogenic damage to the reserve crowns of the ninth and tenth maxillary teeth. The ventral conch sinus and the rostral maxillary sinus can both be assessed by a gate in the conchofrontal or caudal maxillary sinuses after fenestration of the maxillary cartilaginous septal bulla (formerly called ventral conch bulla). The maxillary septal bulla is desensitized with topical local anesthetics and fenestrated with endoscopic guidance using a Ferris-Smith arthroscopic gouge forceps, alligator clip or diode laser through the same gate as the endoscope (Figure 2). If the fenestration of the bubble causes bleeding that interferes with observation, the sinuscopy should be repeated after 24 to 48 hours. It is possible to wash all the compartments after windowing the bubble.4

The references

  1. Tremaine WH, Dixon PM. A long-term study of 277 cases of equine nasosinus disease. Part 1: details of horses, historical, clinical and auxiliary diagnostic results. Equine Vet J. 2001; 33 (3): 274-282. doi: 10.2746 / 042516401776249615
  2. Dixon PM, Parkin TD, Collins N, et al. Equine paranasal sinus disease: a long-term study of 200 cases (1997-2009): treatments and long-term treatment outcomes. Equine Vet J. 2012; 44 (3): 272-276. doi: 10.1111 / j.2042-3306.2011.00427.x
  3. Tatarniuk DM, Bell C, Carmalt JL. A description of the relationship between the nasomaxillary opening and the paranasal sinus system of horses. Veterinarian J. 2010; 186 (2): 216-220. doi: 10.1016 / j.tvjl.2009.07.023
  4. Perkins JD, Windley Z, Dixon PM, Smith M, Barakzai SZ. Sinoscopic treatment of maxillary and ventral rostral concal sinusitis in 60 horses. Veterinary surgeon. 2009; 38 (5): 613-619. doi: 10.1111 / j.1532-950X.2009.00556.x


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New Spin Out 3D Dental Tech: Osteoid https://teethwhiteningireland.com/new-spin-out-3d-dental-tech-osteoid/ https://teethwhiteningireland.com/new-spin-out-3d-dental-tech-osteoid/#respond Fri, 27 Aug 2021 12:38:29 +0000 https://teethwhiteningireland.com/new-spin-out-3d-dental-tech-osteoid/ The dental technology industry is heating up as more and more dental practices adopt 3D dental design and imaging software for greater accuracy and speed in the completion of restorations and implant guides. This week, the maker of medical visualization software Anatomy said it has transformed its dental technology business into a wholly owned subsidiary, […]]]>

The dental technology industry is heating up as more and more dental practices adopt 3D dental design and imaging software for greater accuracy and speed in the completion of restorations and implant guides.

This week, the maker of medical visualization software Anatomy said it has transformed its dental technology business into a wholly owned subsidiary, Osteoid, supported by significant R&D and market investments to fuel an expanded range of new products and features that help make digital dentistry more precise and effective.

Calvin Hur, a more than 20-year veteran of the 3D design and printing industry, will lead Osteoid as CEO, where he will oversee the strategic direction and product roadmap. Anatomage Founder and CEO Jack Choi will continue to serve Osteoid as an advisor.

“Our team is proud to have earned the trust of dental experts to deliver products that streamline the dental workflow,” said Choi. “As a separate dental focused entity, Osteoid can stay at the forefront of 3D visualization technology for the dental industry. “

Image courtesy of Osteoid

The move will allow each company to focus on broad innovation in its core specialty. Anatomage will focus on its medical and educational solutions. Osteoid will only focus on 3D dentistry solutions, including the Invivo 3D dental imaging solutions, as well as its cloud-based platform Invivo Workspace, and solutions for manufacturing precision surgical guides.

Supported by the resources of its parent company Anatomage, Osteoid will make significant investments in R&D and go-to-market initiatives that will provide even greater precision and efficiency in visualizing a single anatomy for implant planning. , orthodontic, endodontic and prosthodontic applications, and more. Recognizing the central role of key thought leaders in the dental ecosystem and suppliers, Osteoid will also integrate customer-centric innovation by developing Osteoid solutions in cooperation with strategic partners.

New offerings in the Osteoid pipeline include Invivo6 Plus for 3D design, additional functionality for Invivo Workspace and additional capabilities for the production of precision surgical guides.

“Osteoid is on a mission to deliver the future of modern dentistry, and I am honored to lead such a client-focused team,” said Hur. “We are more focused and determined than ever to help accelerate the transition to digital dentistry. “


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Ladakh makes public service compulsory for MBBS / BDS / PG aspirants https://teethwhiteningireland.com/ladakh-makes-public-service-compulsory-for-mbbs-bds-pg-aspirants/ https://teethwhiteningireland.com/ladakh-makes-public-service-compulsory-for-mbbs-bds-pg-aspirants/#respond Tue, 24 Aug 2021 21:36:00 +0000 https://teethwhiteningireland.com/ladakh-makes-public-service-compulsory-for-mbbs-bds-pg-aspirants/ Govind SharmaJAMMU, August 24: To overcome the shortage of doctors and specialists in the Union Territory of Ladakh, the UT administration has decided to implement a compulsory public service policy for applicants who obtain the admission to MBBS / BDS / Post Graduate courses in various disciplines of Medicine or Surgery (both clinical and non-clinical) […]]]>

Govind Sharma
JAMMU, August 24: To overcome the shortage of doctors and specialists in the Union Territory of Ladakh, the UT administration has decided to implement a compulsory public service policy for applicants who obtain the admission to MBBS / BDS / Post Graduate courses in various disciplines of Medicine or Surgery (both clinical and non-clinical) based on UT’s reservation quota.
All applicants applying for admission to any medical college / dental college / institutes of medical sciences for any UG / PG courses like MBBS / BDS, MD / MS or degrees in various disciplines on the basis of booking quota of Ladakh, must perform a service obligation to serve in the territory of the Union of Ladakh for a prescribed period immediately after the completion of the course, if the administration so requires.
“All candidates of the UT of Ladakh enjoying the advantage of the reservation of the ST quota / the quota of the UT of Ladakh / any other quota seat will have to sign a service obligation in favor of the administration of the Ladakh indicating that he / she will serve under the administration of UT for a period of 3 years immediately after the successful completion of the PG diploma courses and 2 years immediately after the successful completion of the PG diploma courses and the PG diploma courses. dental specialty ”, indicates a notification issued by the administration of Ladakh.
In addition, applicants for UG (MBBS / BDS) courses selected under the ST / UT quota of Ladakh / any other quota seat outside the Union Territory of Ladakh will be required to sign a service obligation in favor of the administration. Ladakh indicating that he / she will serve under the administration of UT for a period of 5 years in the case of MBBS courses and 3 years in the case of BDS courses immediately after successful completion of the course.
The bond must be executed and submitted in original to the office of the Director of Health Services, Ladakh by all applicants for MBBS / BDS, MD / MS or PG degree courses. This policy will come into effect from the 2021 academic session and beyond.
However, in the event of failure to comply with the stipulated period under the administration of Ladakh according to the link, the failures of PG / DNB diploma courses / diploma in clinical subjects (general medicine, general surgery, orthopedics, otorhinolaryngology) laryngology, obstetrics and gynecology, anesthesiology, pediatrics, ophthalmology, psychiatry, respiratory medicine, radiodiagnosis, radiotherapy, etc.) will pay the administration of the UT an amount of Rs 50 lakh while the fainting occurs in the pre and para clinics (anatomy, physiology, biochemistry, pharmacology, pathology, microbiology, Forensic medicine and toxicology, Community medicine, etc.) and Dental sciences will have to pay Rs 45 lakh and Rs 35 lakh, respectively.
Likewise, if a failure of the MBBS course or the BDS course fails to serve the administration of Ladakh during the prescribed period, he will have to pay an amount of Rs 50 lakh (in case of MBBS course) or Rs 30 lakh (in case of the BDS course) to the administration of UT. However, in the event that a candidate who does not complete the course after being admitted under the reservation quota, he will have to pay half of the deposit amount to the Ladakh administration.
The service bond obligation will not apply to a candidate if his appointment (to the National Health Mission or to the Department of Health on a temporary or quasi-permanent basis) is not made by the administration of the Ladakh within 10 months from the date of communication to the Administration regarding successful completion of the course and eligibility for service. However, each candidate must officially notify the Ladakh administration of the successful completion of the course immediately upon completion.
“If an applicant violates the terms and conditions of the bond, he or she faces severe disciplinary action in accordance with Regulation 8.2 of Chapter 8 of the 2002 Indian Medical Council Regulation or the Indian Dental Council Regulation. In addition, any amount owed to the Administration by the applicant will be recovered from him as arrears of land income, ”said the notification.


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Saint-Bonaventure will welcome new students to campus on Friday for welcome days https://teethwhiteningireland.com/saint-bonaventure-will-welcome-new-students-to-campus-on-friday-for-welcome-days/ https://teethwhiteningireland.com/saint-bonaventure-will-welcome-new-students-to-campus-on-friday-for-welcome-days/#respond Mon, 23 Aug 2021 21:13:37 +0000 https://teethwhiteningireland.com/saint-bonaventure-will-welcome-new-students-to-campus-on-friday-for-welcome-days/ August 23, 2021 | Saint-Bonaventure University will officially welcome the 2025 class to the Bonaventure family during the 2021 Welcome Days this week. On Friday, August 27, first-year students will move into their residences before the 8:30 p.m. candlelight ceremony for students and parents on the steps of the Plassmann Hall. A neighborhood party will […]]]>

August 23, 2021 |

Saint-Bonaventure University will officially welcome the 2025 class to the Bonaventure family during the 2021 Welcome Days this week.

On Friday, August 27, first-year students will move into their residences before the 8:30 p.m. candlelight ceremony for students and parents on the steps of the Plassmann Hall. A neighborhood party will follow.

“The Class of 2025 got a sample of what Saint-Bonaventure has to offer them during our summer orientation programs – hearing what makes this community so great and why the current faculty, staff, students and the elders have taken up residence in this university. During Welcome Days, our incoming class will officially become Bonnies at the end of the Friday night candle light ceremony and see for herself why Bona’s is so special, ”said Dahron Wells, Assistant Director of the Student Success Center.

On Saturday August 28, new students will attend various presentations and activities to help them prepare for the transition to college life. Keynote speaker Linnita Hosten will give students an overview of what it means to be a freshman and how to navigate the experience. Students will learn to write a roadmap for a successful first year; identify valuable resources and opportunities on campus; and make a clear link between their experience, graduation and future career success.

Students will also have the chance to get to know each other during an evening of social and entertainment events, including a game show, hypnotist, movie and bonfire.

Welcome to the wolf pack sign Students will attend workshops and programs on Sunday August 29 to learn more about student life on campus. Orientation for transfer students will also take place on Sunday. The day will conclude with the opening Mass at 5:00 p.m. in the William C. Foster ’62 Memorial Yard at Doyle Hall.

“The events that take place throughout the weekend are designed to introduce our freshmen to their new home, prepare them for the start of class and allow them to connect with their entire class. I hope all members of the SBU community will join me in welcoming the new members of the Bona family, ”said Wells.

The upper classes of the university will start arriving on Saturday. The fall semester courses start on Monday August 30.

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About the University: The country’s premier Franciscan university, Université Saint-Bonaventure is a community committed to transforming the lives of our students inside and outside the classroom, inspiring them with a lifelong commitment to service and the citizenship. In 2020, St. Bonaventure was named the # 2 regional university value in New York City and # 3 in the North by US News and World Report.


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